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Melatonina

Melatonin

INDEX
What is melatonin and what is its role? What are its benefits? When is it recommended to take melatonin? Is it safe? What are the possible side effects? Which foods are richest in melatonin? How to promote its production?
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What is melatonin and what is its role?

Melatonin is a hormone naturally produced by the pineal gland, located in the brain, in response to darkness. Melatonin production is minimal during the first months of life, increases in youth, and then declines again in late adulthood and old age. Commonly called the “sleep hormone,” melatonin regulates the circadian rhythm, a biological process that synchronizes our body with the day-night cycle. During the night, melatonin production increases, inducing sleepiness and preparing the body for rest: shortly after darkness begins, its concentration in the blood rises rapidly, peaking between 2 and 4 a.m., and gradually decreases as morning approaches. This hormone is essential for maintaining a regular sleep-wake cycle and quality sleep.

What are its benefits?

Melatonin has several health benefits. In addition to regulating sleep, it can help reduce jet lag and improve sleep quality during night shifts. Moreover, it has been studied for its potential antioxidant and immunomodulatory effects. Melatonin may play a role in protecting against certain diseases, such as heart disease and neurodegenerative disorders. Preliminary studies also suggest melatonin might improve fertility and reproductive health.

When is it recommended to take melatonin?

Melatonin is often recommended for those struggling with sleep problems, such as insomnia or jet lag. It is particularly useful for people facing rapid changes in time zones, like frequent travelers. Additionally, night shift workers may benefit from melatonin to regulate their circadian rhythm. However, it is important to consult a healthcare professional before starting any melatonin supplement, as it may not be suitable for everyone.

Is it safe? What are the possible side effects?

In general, melatonin is considered safe when taken short-term at recommended doses. However, possible side effects include daytime sleepiness, mild mood changes, and gastrointestinal disturbances. Long-term use may affect natural melatonin production, making medical supervision important. Additionally, since melatonin can interact with certain medications, it is essential to inform your doctor of any other drugs being taken.

Which foods are richest in melatonin?

Although melatonin is available as a supplement, it is possible to increase its intake naturally through certain foods. The main natural source of melatonin is plant-based foods. These include whole grains like brown rice, corn, and oats. Legumes, such as lentils and beans, are also rich in melatonin. Additionally, vegetables like tomatoes and radishes contain significant amounts of this hormone. Other melatonin-containing foods include cherries, red grapes, nuts, and seeds such as sunflower and flax seeds. Consuming these foods may slightly increase melatonin levels in the body; however, the overall effect is generally modest compared to supplements.

How to promote melatonin production?

Promoting melatonin production in the body is important to regulate the sleep-wake cycle and improve sleep quality. Here are some strategies that can help:

  • Expose yourself to natural light. Natural light during the day helps regulate the circadian rhythm and synchronize melatonin production. Spending time outdoors during daylight hours, especially in the morning, can promote a balanced sleep-wake cycle.
  • Encourage darkness at night. Reducing exposure to artificial light during evening and nighttime hours can stimulate melatonin production. Dim screens and use blackout curtains to help.
  • Maintain a regular sleep routine. Going to bed and waking up at the same time each day helps stabilize the circadian rhythm and melatonin production.
  • Avoid blue light before sleep. Blue light emitted by electronic screens can suppress melatonin production. Avoid using electronic devices at least one hour before bed to encourage melatonin production.
  • Create a comfortable sleep environment. Keeping the bedroom cool, quiet, and dark can help stimulate melatonin production. Minimizing noise and disturbances improves sleep quality.
  • Practice relaxation techniques. Relaxation methods like meditation, yoga, and deep breathing can reduce stress and promote balanced melatonin production.
  • Maintain a balanced diet. Foods rich in tryptophan (a melatonin precursor) can support melatonin production. Examples include nuts, seeds, poultry, fish, and dairy products.
  • Limit caffeine and alcohol. Avoid consuming caffeine and alcohol in the evening to prevent interference with melatonin production and support sleep.
  • Engage in physical activity. Regular exercise can improve sleep quality and positively influence the circadian rhythm.
  • Use supplements cautiously. In some cases, under healthcare supervision, melatonin supplements can help with sleep disorders, but it is important to follow proper dosing and guidance.

 

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Bibliography
  • Andersen, L.P., Gögenu,r I., Rosenberg, J., et al. (2016). The safety of melatonin in humans, Clinical Drug Investigation. 2016;36(3):169-175
  • Costello, R.B., Lentino, C.V., Boyd, C.C., et al. (2014). The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutrition Journal. 2014; 13:106.
  • Ferlazzo, N., Andolina, G., Cannata, A., Costanzo, M.G., Rizzo, V., Currò, M., Ientile, R., Caccamo, D. (2020). Is Melatonin the Cornucopia of the 21st Century? Antioxidants 2020, 9, 1088. https://doi.org/10.3390/antiox9111088
  • Galano, A., Tan, D.X., Reiter, R.J. (2011). Melatonin as a natural ally against oxidative stress: a physicochemical examination, J. Pineal Res. 2011 Aug;51(1):1-16. doi: 10.1111/j.1600-079X.2011.00916.x
  • Kennaway, D. (2015). Potential safety issues in the use of the hormone melatonin in pediatrics, Journal of Paediatrics and Child Health. 2015;51(6):584-589.
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